Can leukemia in children with Down syndrome be prevented? Princess Margaret Scientists reveal a new target that suggests it can

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IMAGE: DR. ELVIN WAGENBLAST, POST-DOCTORAL FELLOW AT THE PRINCESS MARGARET CANCER CENTRE, UNIVERSITY HEALTH NETWORK, IS THE FIRST AUTHOR. view more

CREDIT: UHN

For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future.

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia within the first five years of their life. Yet the mechanism by which the extra copy of chromosome 21 predisposes to leukemia remains unclear.

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